Expressive

rs116907254 - RNASE1 - RNASE3

Magnitude 2.2 · 1 study on file

Reported associations

  • Polygenic risk score model for renal cell carcinoma in the Korean population and relationship with lifestyle-associated factors - Unknown journal (n.d.) · Unknown authors · PubMed 38200428

    ABSTRACT: Background The polygenic risk score (PRS) is used to predict the risk of developing common complex diseases or cancers using genetic markers. Although PRS is used in clinical practice to predict breast cancer risk, it is more accurate for Europeans than for non-Europeans because of the sample size of training genome-wide association studies (GWAS). To address this disparity, we constructed a PRS model for predicting the risk of renal cell carcinoma (RCC) in the Korean population. Results Using GWAS analysis, we identified 43 Korean-specific variants and calculated the PRS. Subsequent to plotting receiver operating characteristic (ROC) curves, we selected the 31 best-performing variants to construct an optimal PRS model. The resultant PRS model with 31 variants demonstrated a pred

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Blood pressure monitoring and hypertension management Moderate

    Hypertension is an independent RCC risk factor; controlling blood pressure reduces cancer risk

    Regular BP monitoring; target < 130/80 mmHg; treat diagnosed hypertension

Lifestyle

  • Cigarette smoking Moderate

    Smoking is one of the strongest modifiable RCC risk factors; cessation significantly reduces risk

    Smoking cessation program; discuss pharmacotherapy options with physician

  • Maintain body mass index below 30 kg/m2 Moderate

    Obesity is a major RCC risk factor; maintaining healthy weight reduces cancer risk across genetic backgrounds

    Target BMI < 30; combine diet modification and regular exercise

  • Moderate alcohol consumption Moderate

    Excessive alcohol increases RCC risk; moderate intake is part of an optimal preventive lifestyle

    Limit to <= 1 drink/day for women, <= 2 drinks/day for men

Screening

  • Periodic renal ultrasound screening Moderate

    This variant is associated with significantly increased RCC risk; periodic imaging enables early detection

    Discuss RCC risk assessment and screening protocol with healthcare provider