rs116907128 - MIR4435-2HG, BCL2L11

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide Association of Kidney Traits in Hispanics/Latinos Using Dense Imputed Whole Genome Sequencing Data: The Hispanic Community Health Study/Study of Latinos - Unknown journal (n.d.) · Unknown authors · PubMed 32600054

  ABSTRACT: Background - Genetic factors that influence kidney traits have been understudied for low frequency and ancestry-specific variants. Methods - This study used imputed whole genome sequencing from the Trans-Omics for Precision Medicine project to identify novel loci for estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (ACR) in up to 12,207 Hispanics/Latinos. Replication was performed in the Women's Health Initiative and the UK Biobank when variants were available. Results - Two low frequency intronic variants were associated with eGFR (rs58720902 at AQR, minor allele frequency [MAF] = 0.01, P=1.6 × 10−8) or ACR (rs527493184 at ZBTB16, MAF=0.002, P=1.1 × 10−8). An additional variant at PRNT (rs2422935, MAF=0.54, P=2.89 × 10−8) was significa

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