Expressive

rs11689770 - FOSL2

Magnitude 2.2 · 1 study on file

Reported associations

  • The power of genetic diversity in genome-wide association studies of lipids - Unknown journal (n.d.) · Unknown authors · PubMed 34887591

    ABSTRACT: Elevated blood lipid levels are heritable risk factors of cardiovascular disease with varying prevalence worldwide due to differing dietary patterns and medication use. Despite advances in prevention and treatment, particularly through the lowering of low-density lipoprotein cholesterol levels, heart disease remains the leading cause of death worldwide. Genome-wide association studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS have been conducted in European ancestry populations and may have missed genetic variants contributing to lipid level variation in other ancestry groups due to differences in allele frequencies, effect sizes, and linkage-disequilibr

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • lipid panel Moderate

    C allele carriers show elevated total and LDL cholesterol levels

    Baseline lipid panel, then periodic follow-up testing as recommended by healthcare provider

Diet

  • cholesterol-lowering diet pattern Moderate

    C allele associated with elevated total and LDL cholesterol; dietary fiber and plant sterols lower LDL

    Emphasize soluble fiber (oats, beans), plant sterols, lean proteins; limit saturated fat

Discuss with your doctor

  • cardiovascular risk management Moderate

    Genetic predisposition to elevated cholesterol warrants personalized risk stratification