Expressive

rs11689333 - RSL24D1P2 - EHBP1

Magnitude 4.5 · 1 study on file

Reported associations

  • Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 35884923

    ABSTRACT: A comprehensive understanding of gene-diet interactions is necessary to establish proper dietary guidelines to prevent and manage cardio-cerebrovascular disease (CCD). We investigated the role of genetic variants associated with dyslipidaemia (DL) and their interactions with macro-nutrients for cardiovascular disease using a large-scale genome-wide association study of Korean adults. A total of 58,701 participants from a Korean genome and epidemiology study were included. Their dietary intake was assessed using a food frequency questionnaire. Dyslipidaemia was defined as total cholesterol (TCHL) ≥ 240 mg/dL, high-density lipoprotein (HDL) < 40 mg/dL, low-density lipoprotein (LDL) ≥ 160 mg/dL, triglycerides (TG) ≥ 200 mg/dL, or dyslipidaemia history. Their nutrient intake wa

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • reduce saturated fat intake Moderate

    Saturated fat raises total cholesterol; this SNP indicates genetic predisposition to higher cholesterol

    Limit to less than 7 percent of daily calories

Exercise

  • regular aerobic exercise Moderate

    Aerobic activity lowers cholesterol and improves cardiovascular health given genetic predisposition

    150 minutes moderate-intensity activity per week

Screening

  • lipid panel screening Moderate

    Variant is strongly associated with higher total cholesterol; regular monitoring identifies risk early

    Annual lipid panel, more frequently if baseline elevated