rs116880189 - SENP6
Magnitude 2.2 · 1 study on file
Reported associations
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Gut microbiota is associated with bone mineral density - Unknown journal (n.d.) · Unknown authors · PubMed 34779240
ABSTRACT: Aims Despite the interest in the association of gut microbiota with bone health, limited population-based studies of gut microbiota and bone mineral density (BMD) have been made. Our aim is to explore the possible association between gut microbiota and BMD. Methods A total of 3,321 independent loci of gut microbiota were used to calculate the individual polygenic risk score (PRS) for 114 gut microbiota-related traits. The individual genotype data were obtained from UK Biobank cohort. Linear regressions were then conducted to evaluate the possible association of gut microbiota with L1-L4 BMD (n = 4,070), total BMD (n = 4,056), and femur total BMD (n = 4,054), respectively. PLINK 2.0 was used to detect the single-nucleotide polymorphism (SNP) × gut microbiota interaction effect on
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Lactococcus-containing fermented foods or probiotics Moderate
SENP6 rs116880189 C allele interacts with gut Lactococcus abundance to influence femur bone mineral density; optimizing Lactococcus may support bone health
Include fermented foods (yogurt, kefir, sauerkraut) or Lactococcus-containing probiotics as regular dietary component
Screening
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Baseline femur bone mineral density assessment via DEXA Moderate
SENP6 variant directly influences femur BMD through microbiota interaction; baseline assessment establishes bone health status and informs monitoring
Discuss with healthcare provider; obtain DEXA scan if not done recently; repeat every 3-5 years based on results