rs116879283 - RN7SL292P - SGO1P2

Magnitude 4.5 · 1 study on file

Reported associations

• A genome-wide association study in a large community-based cohort identifies multiple loci associated with susceptibility to bacterial and viral infections - Unknown journal (n.d.) · Unknown authors · PubMed 35173190

  ABSTRACT: There is limited data on host-specific genetic determinants of susceptibility to bacterial and viral infections. Genome-wide association studies using large population cohorts can be a first step towards identifying patients prone to infectious diseases and targets for new therapies. Genetic variants associated with clinically relevant entities of bacterial and viral infections (e.g., abdominal infections, respiratory infections, and sepsis) in 337,484 participants of the UK Biobank cohort were explored by genome-wide association analyses. Cases (n = 81,179) were identified based on ICD-10 diagnosis codes of hospital inpatient and death registries. Functional annotation was performed using gene expression (eQTL) data. Fifty-seven unique genome-wide significant loci were found

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