rs11685995 - CCL20 - CRIPTOP2
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema - Unknown journal (n.d.) · Unknown authors · PubMed 31361310
ABSTRACT: Abstract Even though heritability estimates suggest that the risk of asthma, hay fever and eczema is largely due to genetic factors, previous studies have not explained a large part of the genetics behind these diseases. In this genome-wide association study, we include 346 545 Caucasians from the UK Biobank to identify novel loci for asthma, hay fever and eczema and replicate novel loci in three independent cohorts. We further investigate if associated lead single nucleotide polymorphisms (SNPs) have a significantly larger effect for one disease compared to the other diseases, to highlight possible disease-specific effects. We identified 141 loci, of which 41 are novel, to be associated (P ≤ 3 × 10−8) with asthma, hay fever or eczema, analyzed separately or as dis
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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allergic disease risk with healthcare provider Moderate
The C allele at rs11685995 increases odds of allergic disease 1.042-fold in a large GWAS study
Screening
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asthma, hay fever, and eczema symptoms Moderate
The C allele increases genetic susceptibility to allergic disease
Annual symptom assessment; seek evaluation if new respiratory, nasal, or skin symptoms develop