Expressive

rs11684146 - PABPC1P2 - LINC01911

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways. - Nature genetics (2019) · Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA, Benjamins JS, Muñoz-Manchado AB, Nagel M, Savage JE, Tiemeier H, White T, Tung JY, Hinds DA, Vacic V, Wang X, Sullivan PF, van der Sluis S, Polderman TJC, Smit AB, Hjerling-Leffler J, Van Someren EJW, Posthuma D · PubMed 30804565

    Insomnia is the second most prevalent mental disorder, with no sufficient treatment available. Despite substantial heritability, insight into the associated genes and neurobiological pathways remains limited. Here, we use a large genetic association sample (n = 1,331,010) to detect novel loci and gain insight into the pathways, tissue and cell types involved in insomnia complaints. We identify 202 loci implicating 956 genes through positional, expression quantitative trait loci, and chromatin mapping. The meta-analysis explained 2.6% of the variance. We show gene set enrichments for the axonal part of neurons, cortical and subcortical tissues, and specific cell types, including striatal, hypothalamic, and claustrum neurons. We found considerable genetic correlations with psychiatric tr

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • rs11684146 genetic predisposition to insomnia Moderate

    genome-wide significant association (n=1.3M, p=1e-8) warrants discussion of prevention and early intervention strategies

    mention rs11684146 finding, discuss preventive lifestyle modifications and treatment options if insomnia develops

Lifestyle

  • evidence-based sleep hygiene practices Moderate

    rs11684146 risk allele G increases insomnia risk by 4.5% per copy; sleep hygiene is first-line evidence-based intervention

    maintain consistent sleep schedule, dark/cool bedroom, avoid screens 1 hour before bed, limit caffeine after 2pm

Screening

  • sleep quality and insomnia symptom tracking Moderate

    genetic predisposition requires proactive monitoring to detect insomnia onset and enable early intervention

    track sleep onset latency, total duration, and subjective quality weekly; flag consistent issues