rs116834158 - RNU6-1120P - KCNMB2
Magnitude 4.5 · 1 study on file
Reported associations
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Genome Wide Association Study of Neuropathic Ocular Pain - Unknown journal (n.d.) · Unknown authors · PubMed 37868788
ABSTRACT: Purpose To conduct a genome-wide association study (GWAS) of individuals with neuropathic ocular pain (NOP) symptoms to identify genomic variants that may predispose to NOP development. Design Prospective study of individuals with NOP. Participants Three hundred twenty-nine patients recruited from the Miami Veterans Affairs eye clinic. Methods The Neuropathic Pain Symptom Inventory modified for the eye (NPSI-Eye) was completed to calculate a NPSI-Eye-Sub-Score (summed ratings of burning and wind sensitivity) as an indicator of NOP severity. A GWAS was performed for the NPSI-Eye-Sub-Score with a significance threshold of P < 5 × 10−8. A gene-based analysis was performed using the multimarker analysis of genomic annotation software (in the functional mapping and annotation of
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic risk for neuropathic ocular pain Moderate
Variant rs116834158 is associated with neuropathic ocular pain; discussion can guide preventive care and symptom management.
Discuss with ophthalmologist or neurologist
Screening
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neuropathic ocular pain Moderate
rs116834158 is significantly associated with neuropathic ocular pain (OR=1.77); monitoring enables early intervention.
Assess for eye pain, dry eye, photophobia; consider baseline ophthalmologic evaluation