Expressive

rs11682878 - RNU6-1145P - RPS24P7

Magnitude 2.2 · 1 study on file

Reported associations

  • A genome‐wide association meta‐analysis of all‐cause and vascular dementia - Unknown journal (n.d.) · Unknown authors · PubMed 39046104

    ABSTRACT: Abstract INTRODUCTION Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome‐wide association studies (GWAS) focus on AD. METHODS We conducted a GWAS of all‐cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors. RESULTS For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonanc

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean-style diet pattern Moderate

    Mediterranean diet reduces dementia risk and cognitive decline; protective effect particularly relevant for individuals with genetic dementia susceptibility

    emphasize vegetables, whole grains, fish, olive oil; limit processed foods and red meat

Discuss with your doctor

  • dementia risk assessment and screening plan Moderate

    rs11682878-C allele associated with dementia in well-powered GWAS; discussion of personalized risk and appropriate screening timing is warranted

Exercise

  • regular aerobic and cognitive exercise Moderate

    exercise reduces dementia incidence and cognitive decline; especially important for genetically susceptible individuals with increased dementia risk

    150 minutes moderate-intensity aerobic activity weekly plus daily cognitive stimulation

Screening

  • baseline cognitive assessment Moderate

    rs11682878-C allele increases dementia risk in large GWAS (p=6e-7, n=524k); baseline cognitive testing enables early detection of decline

    discuss cognitive screening timeline with healthcare provider