Expressive

rs11682804 - PRKCE

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetic determinants of glucose levels in pregnancy: genetic risk scores analysis and GWAS in the Norwegian STORK cohort. - European journal of endocrinology (2018) · Moen GH, LeBlanc M, Sommer C, Prasad RB, Lekva T, Normann KR, Qvigstad E, Groop L, Birkeland KI, Evans DM, Frøslie KF · PubMed 30324795

    Objective Hyperglycaemia during pregnancy increases the risk of adverse health outcomes in mother and child, but the genetic aetiology is scarcely studied. Our aims were to (1) assess the overlapping genetic aetiology between the pregnant and non-pregnant population and (2) assess the importance of genome-wide polygenic contributions to glucose traits during pregnancy, by exploring whether genetic risk scores (GRSs) for fasting glucose (FG), 2-h glucose (2hG), type 2 diabetes (T2D) and BMI in non-pregnant individuals were associated with glucose measures in pregnant women. Methods We genotyped 529 Norwegian pregnant women and constructed GRS from known genome-wide significant variants and SNPs weakly associated (p > 5 × 10-8) with FG, 2hG, BMI and T2D from external genome-wide association

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Glucose monitoring during pregnancy Moderate

    G allele carriers show elevated glucose at gestational weeks 30-32; regular monitoring helps detect glucose intolerance early.

    Discuss glucose screening schedule with obstetrician; may warrant closer follow-up based on risk factors.

Diet

  • Low glycemic index diet during pregnancy Moderate

    G allele associated with elevated two-hour glucose in pregnancy; dietary carbohydrate quality may help moderate postprandial glucose excursions.

    Emphasize whole grains, legumes, non-starchy vegetables, lean proteins; limit simple sugars and refined grains.

Exercise

  • Regular physical activity during pregnancy Moderate

    G allele associated with higher glucose levels in pregnancy; physical activity improves glucose tolerance and insulin sensitivity.

    Aim for 150 minutes moderate-intensity aerobic activity per week, as tolerated and approved by obstetrician.