rs116819086 - RARB

Magnitude 2.2 · 1 study on file

Reported associations

• Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multi-Ethnic Population and Causal Associations with Atrial Fibrillation - Unknown journal (n.d.) · Unknown authors · PubMed 34732054

  ABSTRACT: Background Elevated cardiac troponin levels in blood are associated with increased risk of cardiovascular diseases (CVDs) and mortality. Cardiac troponin levels are heritable, but their genetic architecture remains elusive. Methods We conducted a trans-ethnic genome-wide association analysis on high-sensitivity cardiac troponin T and I levels (hs-cTnT and hs-cTnI) in 24,617 and 14,336 participants free of coronary heart disease and heart failure from six population-based cohorts, followed by a series of bioinformatic analyses to decipher the genetic architecture of hs-cTnT and hs-cTnI. Results We identified four genome-wide significant loci for hs-cTnT including a novel locus, rs3737882 in PPFIA4, and three previously reported loci at NCOA2, TRAM1 and BCL2. One known locus at VCL

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