Expressive

rs11681373 - ZNF804A

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample - Unknown journal (n.d.) · Unknown authors · PubMed 37282553

    ABSTRACT: Objective: Recent genome-wide association studies (GWASs) of alcohol-related phenotypes have uncovered key differences in the underlying genetic architectures of alcohol consumption and alcohol use disorder (AUD), with the two traits having opposite genetic correlations with psychiatric disorders. Understanding the genetic factors that underlie the transition from heavy drinking to AUD has important theoretical and clinical implications. Methods: The authors used longitudinal data from the cross-ancestry Million Veteran Program sample to identify 1) novel loci associated with AUD and alcohol consumption (measured by the score on the consumption subscale of the Alcohol Use Disorders Identification Test [AUDIT-C]), 2) the impact of phenotypic variation on genetic discovery, and 3)

  • Bi-Ancestral Depression GWAS in the Million Veteran Program and Meta-Analysis in >1.2 Million Subjects Highlights New Therapeutic Directions - Unknown journal (n.d.) · Unknown authors · PubMed 34045744

    ABSTRACT: Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of veterans. We report results of a large meta-analysis of depression using data from the Million Veteran Program (MVP), 23andMe Inc., UK Biobank, and FinnGen; including individuals of European ancestry (n=1,154,267; 340,591 cases) and African ancestry (n=59,600; 25,843 cases). Transcriptome-wide association study (TWAS) analyses revealed significant associations with expression of NEGR1 in the hypothalamus and DRD2 in the nucleus accumbens, among others. 178 genomic risk loci were fine-mapped, and we identified likely pathogenicity in these variants and overlapping gene expression for 17 genes from our TWAS, including TRAF3. Finally, we were able to show substantial replications of our findings

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • alcohol use disorder genetic risk Moderate

    rs11681373 risk allele associated with increased alcohol use disorder susceptibility (GWAS p=4.00e-8, effect=5.488, n=409,630)

    Review personal and family AUD history; discuss screening and prevention strategies

  • major depression genetic predisposition and monitoring Moderate

    Genetic risk for depression warrants proactive discussion of symptoms, screening, and prevention strategies

    Review family mental health history; establish baseline mood and symptom monitoring plan

Lifestyle

  • alcohol consumption patterns and AUD signs Moderate

    Genetic predisposition warrants proactive awareness of drinking patterns and early indicators of problematic use

    Track frequency, quantity, and context of drinking; note any loss of control or negative consequences

Screening

  • major depressive disorder screening Moderate

    rs11681373 associated with major depressive disorder risk (GWAS p=2.00e-8, n=1,154,267)

    Discuss depression screening tools and baseline assessment with healthcare provider