Expressive

rs11681089 - AAK1

Magnitude 4.5 · 1 study on file

Reported associations

  • Genome-wide association meta-analysis identifies two novel loci associated with dental caries. - BMC oral health (2024) · Nogawa S, Morishita S, Saito K, Kato H · PubMed 39192244

    Tooth loss significantly impacts oral function and overall health deterioration. Dental caries and periodontal disease are major contributors to tooth loss, emphasizing the critical need to prevent these conditions. Genetic studies have played a crucial role in deepening our understanding of the underlying mechanisms of these diseases. While large-scale genome-wide association studies (GWAS) on dental caries and periodontal disease have been conducted extensively, research focusing on Asian populations remains limited. Given substantial genetic and lifestyle variations across ethnicities, conducting studies across diverse populations is imperative. This study aimed to uncover new insights into the genetic mechanisms of these diseases, contributing to broader knowledge and potential targete

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Minimize free sugars in diet Moderate

    Dietary sugars are primary drivers of caries; genetic predisposition may require stricter sugar control

    Limit added sugars to less than 10% of daily calories; minimize sugary drinks

Lifestyle

  • Enhance oral hygiene practices Moderate

    Superior oral hygiene reduces caries incidence; particularly important for individuals with genetic susceptibility

    Brush twice daily and floss daily; use interdental cleaning aids

  • Use fluoride dental products Moderate

    Fluoride strengthens enamel and reduces caries risk; important for genetically predisposed individuals

    Use fluoride toothpaste (1000-1500 ppm) twice daily

Screening

  • Regular dental checkups for caries detection Moderate

    Genetic variant rs11681089 is associated with increased dental caries susceptibility; regular screening enables early intervention

    At least twice yearly dental examinations