Expressive

rs11680911 - BIN1 - NIFKP9

Magnitude 2.8 · 2 studies on file

Reported associations

  • Identification of 16 novel Alzheimer's disease loci using multi‐ancestry meta‐analyses - Unknown journal (n.d.) · Unknown authors · PubMed 39998322

    ABSTRACT: Abstract INTRODUCTION Alzheimer's disease (AD) is the most prevalent form of dementia. While many AD‐associated genetic determinants have been identified, few studies have analyzed individuals of non‐European ancestry. METHODS We conducted a multi‐ancestry genome‐wide association study (GWAS) of clinically diagnosed AD and AD‐by‐proxy using whole genome sequencing data from the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS), National Institute of Mental Health, UK Biobank (UKB), and All of Us (AoU) consisting of 49,149 cases (12,074 clinically diagnosed and 37,075 AD‐by‐proxy) and 383,225 controls. Nearly half of NIAGADS and AoU participants were of non‐European ancestry. RESULTS For clinically diagnosed AD, we identified

  • Genome-wide Association and Multi-Omics Studies Identify MGMT as a Novel Risk Gene for Alzheimer Disease Among Women - Unknown journal (n.d.) · Unknown authors · PubMed 35770850

    ABSTRACT: INTRODUCTION: Variants in the tau gene (MAPT) region are associated with breast cancer in women and Alzheimer disease (AD) among persons lacking APOE ε4 (ε4-). METHODS: To identify novel genes associated with tau-related pathology, we conducted two genome-wide association studies (GWAS) for AD, one among 10,340 ε4- women in the Alzheimer's Disease Genetics Consortium (ADGC) and another in 31 members (22 women) of a consanguineous Hutterite kindred. RESULTS: We identified novel associations of AD with MGMT variants in ADGC (rs12775171, odds ratio [OR]=1.4, P=4.9×10−8) and Hutterites (rs12256016 and rs2803456, OR=2.0, P=1.9×10−14). Multi-omics analyses showed that the most significant and largest number of associations among the SNPs, DNA-methylated CpGs, MGMT expression

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