rs11680809 - IL1A - IL1B

Magnitude 2.2 · 1 study on file

Reported associations

• Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors - Unknown journal (n.d.) · Unknown authors · PubMed 31043758

  ABSTRACT: Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n=321,223) and offspring birth weight (n=230,069 mothers), we identified 190 independent association signals (129 novel). We used structural equation modelling to decompose the contributions of direct fetal and indirect maternal genetic effects, and then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth we

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