rs116786842 - GABBR2

Magnitude 4.5 · 1 study on file

Reported associations

• Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids. - Translational psychiatry (2025) · Bentley AR, Brown MR, Musani SK, Schwander KL, Winkler TW, Sims M, Kilpeläinen TO, Aschard H, Bartz TM, Bielak LF, Chai JF, Chitrala KN, Franceschini N, Graff M, Guo X, Hartwig FP, Horimoto ARVR, Lim E, Liu Y, Manning AK, Nolte IM, Noordam R, Richard MA, Smith AV, Sung YJ, Vojinovic D, Wang R, Wang Y, Feitosa MF, Harris SE, Lyytikäinen LP, Pistis G, Rauramaa R, van der Most PJ, Ware E, Weiss S, Wen W, Yanek LR, Arking DE, Arnett DK, Ballantyne C, Boerwinkle E, Chen YI, Daviglus ML, de Las Fuentes L, de Vries PS, Delaney JAC, Fretts AM, Ekunwe L, Faul JD, Gallo LC, Heikkinen S, Homuth G, Ikram MA, Isasi CR, Jonas JB, Keltikangas-Järvinen L, Komulainen P, Kraja AT, Krieger JE, Launer L, Liu J, Lohman K, Luik AI, Manichaikul AW, Marques-Vidal P, Milaneschi Y, Mwasongwe SE, O'Connell JR, Rice K, Rich SS, Schreiner PJ, Schwettmann L, Shikany JM, Shu XO, Smith JA, Snieder H, Sotoodehnia N, Tai ES, Taylor KD, Tinker L, Tsai MY, Uitterlinden AG, van Duijn CM, van Heemst D, Waldenberger M, Wallace RB, Wee HL, Weir DR, Wei WB, Willems van Dijk K, Wilson G, Yao J, Young KL, Zhang X, Zhao W, Zhu X, Zonderman AB, Deary IJ, Gieger C, Grabe HJ, Lakka TA, Lehtimäki T, Oldehinkel AJ, Preisig M, Wang YX, Zheng W, Evans MK, Province M, Gauderman J, Gudnason V, Hartman CA, Horta BL, Kardia SLR, Kooperberg C, Liu CT, Mook-Kanamori DO, Penninx BW, Pereira AC, Peyser PA, Psaty BM, Rotter JI, Sim X, North KE, Rao DC, Bierut L, Miller CL, Morrison AC, Rotimi CN, Fornage M, Fox ER · PubMed 40537477

  Serum lipid levels, which are influenced by both genetic and environmental factors, are key determinants of cardiometabolic health and are influenced by both genetic and environmental factors. Improving our understanding of their underlying biological mechanisms can have important public health and therapeutic implications. Although psychosocial factors, including depression, anxiety, and perceived social support, are associated with serum lipid levels, it is unknown if they modify the effect of genetic loci that influence lipids. We conducted a genome-wide gene-by-psychosocial factor interaction (G×Psy) study in up to 133,157 individuals to evaluate if G×Psy influences serum lipid levels. We conducted a two-stage meta-analysis of G×Psy using both a one-degree of freedom (1df) interacti

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