Expressive

rs11678354 - MEIS1

Magnitude 2.8 · 2 studies on file

Reported associations

  • Genetic analyses of diverse populations improves discovery for complex traits - Unknown journal (n.d.) · Unknown authors · PubMed 31217584

    ABSTRACT: Genome-wide association studies (GWAS) have laid the foundation for investigations into the biology of complex traits, drug development and clinical guidelines. However, the majority of discovery efforts are based on data from populations of European ancestry. In light of the differential genetic architecture that is known to exist between populations, bias in representation can exacerbate existing disease and healthcare disparities. Critical variants may be missed if they have a low frequency or are completely absent in European populations, especially as the field shifts its attention towards rare variants, which are more likely to be population-specific. Additionally, effect sizes and their derived risk prediction scores derived in one population may not accurately extrapolate

  • Genetic Determinants of P Wave Duration and PR Segment - Unknown journal (n.d.) · Unknown authors · PubMed 24850809

    ABSTRACT: Background The PR interval on the electrocardiogram reflects atrial depolarization and AV nodal delay which can be partially differentiated by P wave duration and PR segment, respectively. GWAS have identified a number of genetic loci for PR interval but it remains to be determined whether this is driven by P wave duration, PR segment or both. Methods and Results We replicated 7 of the 9 known PR interval loci in 16,468 individuals of European ancestry. Four loci were unambiguously associated with PR segment while the others were shared for P wave duration and PR segment. Next, we performed a genome-wide analysis on P wave duration and PR segment separately and identified five novel loci. SNPs in KCND3 (P=8.3×10−11) and FADS2 (P=2.7×10−8) were associated with P wave duratio

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