rs116781682 - FTLP19 - RNU6-1075P

Magnitude 2.2 · 1 study on file

Reported associations

• A Genome-Wide Association Study Identifies Blood Disorder-Related Variants Influencing Hemoglobin A With Implications for Glycemic Status in U.S. Hispanics/Latinos. - Diabetes care (2020) · Moon JY, Louie TL, Jain D, Sofer T, Schurmann C, Below JE, Lai CQ, Aviles-Santa ML, Talavera GA, Smith CE, Petty LE, Bottinger EP, Chen YI, Taylor KD, Daviglus ML, Cai J, Wang T, Tucker KL, Ordovás JM, Hanis CL, Loos RJF, Schneiderman N, Rotter JI, Kaplan RC, Qi Q · PubMed 31213470

  We aimed to identify hemoglobin A (HbA )-associated genetic variants and examine their implications for glycemic status evaluated by HbA in U.S. Hispanics/Latinos with diverse genetic ancestries. We conducted a genome-wide association study (GWAS) of HbA in 9,636 U.S. Hispanics/Latinos without diabetes from the Hispanic Community Health Study/Study of Latinos, followed by a replication among 4,729 U.S. Hispanics/Latinos from three independent studies. Our GWAS and replication analyses showed 10 previously known and novel loci associated with HbA at genome-wide significance levels ( < 5.0 × 10 ). In particular, two African ancestry-specific variants, rs334 and -rs1050828, which are causal mutations for sickle cell disease and deficiency, respectively, had ∼10 times larger effect sizes on

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