rs11678106 - RN7SL201P - LYARP1

Magnitude 4.5 · 2 studies on file

Reported associations

• Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function - Unknown journal (n.d.) · Unknown authors · PubMed 29844566

  ABSTRACT: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function

• Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence - Unknown journal (n.d.) · Unknown authors · PubMed 29942086

  [INTRO] Intelligence is highly heritable and a major determinant of human health and well-being. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence, but much about its genetic underpinnings remains to be discovered. Here, we present the largest genetic association study of intelligence to date (N=269,867), identifying 205 associated genomic loci (190 novel) and 1,016 genes (939 novel) via positional mapping, expression quantitative trait locus (eQTL) mapping, chromatin interaction mapping, and gene-based association analysis. We find enrichment of genetic effects in conserved and coding regions and associations with 146 nonsynonymous exonic variants. Associated genes are strongly expressed in the brain, specifically in striatal medium spiny

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