rs11677686 - SCHLAP1
Magnitude 2.2 · 1 study on file
Reported associations
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Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation - Unknown journal (n.d.) · Unknown authors · PubMed 40645996
ABSTRACT: Atrial fibrillation (AF) is a common cardiac arrhythmia with strong genetic components, yet its underlying molecular mechanisms and potential therapeutic targets remain incompletely understood. We conducted a cross-population genome-wide meta-analysis of 252,438 AF cases and identified 525 loci that met genome-wide significance. Two loci of PITX2 and ZFHX3 genes were identified as shared across populations of different ancestries. Comprehensive gene prioritization approaches reinforced the role of muscle development and heart contraction while also uncovering additional pathways, including cellular response to transforming growth factor-beta. Population-specific genetic correlations uncovered common and unique circulatory comorbidities between Europeans and Africans. Mendelian ra
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic risk assessment and personalized AF prevention High
rs11677686 confers significant atrial fibrillation risk; cardiology consultation can establish appropriate screening and prevention protocols
Exercise
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Regular moderate aerobic exercise High
Regular moderate-intensity exercise reduces atrial fibrillation risk and improves cardiovascular outcomes
150 minutes of moderate aerobic activity per week (e.g., brisk walking, cycling); avoid extreme endurance training
Lifestyle
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Excessive alcohol consumption High
Alcohol is a well-established atrial fibrillation trigger; genetic predisposition amplifies this risk
Limit to maximum 2 drinks per day (men) or 1 drink per day (women); avoid binge drinking
Screening
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Atrial fibrillation screening with ECG High
rs11677686 (SCHLAP1) is significantly associated with increased atrial fibrillation risk; early detection enables stroke prevention and symptom management
Baseline 12-lead ECG, repeat annually or if symptoms develop; discuss with cardiologist
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Blood pressure control and monitoring High
Hypertension significantly increases atrial fibrillation risk, particularly in genetically predisposed individuals
Monitor blood pressure regularly; target <130/80 mmHg; discuss treatment with physician if elevated