rs11677541 - GRB14
Magnitude 2.2 · 1 study on file
Reported associations
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Genomics and phenomics of body mass index reveals a complex disease network - Unknown journal (n.d.) · Unknown authors · PubMed 36581621
ABSTRACT: Elevated body mass index (BMI) is heritable and associated with many health conditions that impact morbidity and mortality. The study of the genetic association of BMI across a broad range of common disease conditions offers the opportunity to extend current knowledge regarding the breadth and depth of adiposity-related diseases. We identify 906 (364 novel) and 41 (6 novel) genome-wide significant loci for BMI among participants of European (N~1.1 million) and African (N~100,000) ancestry, respectively. Using a BMI genetic risk score including 2446 variants, 316 diagnoses are associated in the Million Veteran Program, with 96.5% showing increased risk. A co-morbidity network analysis reveals seven disease communities containing multiple interconnected diseases associated with BMI
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Body mass index Moderate
rs11677541 G allele significantly associated with higher BMI in GWAS of over 1 million individuals; GRB14 expressed in metabolic tissues including adipose
Annual BMI measurement; fasting metabolic panel every 2-3 years starting in early adulthood