rs116745876 - C5orf67 - MAP3K1
Magnitude 2.8 · 1 study on file
Reported associations
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Genetic determinants of glucose levels in pregnancy: genetic risk scores analysis and GWAS in the Norwegian STORK cohort. - European journal of endocrinology (2018) · Moen GH, LeBlanc M, Sommer C, Prasad RB, Lekva T, Normann KR, Qvigstad E, Groop L, Birkeland KI, Evans DM, Frøslie KF · PubMed 30324795
Objective Hyperglycaemia during pregnancy increases the risk of adverse health outcomes in mother and child, but the genetic aetiology is scarcely studied. Our aims were to (1) assess the overlapping genetic aetiology between the pregnant and non-pregnant population and (2) assess the importance of genome-wide polygenic contributions to glucose traits during pregnancy, by exploring whether genetic risk scores (GRSs) for fasting glucose (FG), 2-h glucose (2hG), type 2 diabetes (T2D) and BMI in non-pregnant individuals were associated with glucose measures in pregnant women. Methods We genotyped 529 Norwegian pregnant women and constructed GRS from known genome-wide significant variants and SNPs weakly associated (p > 5 × 10-8) with FG, 2hG, BMI and T2D from external genome-wide association
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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fasting glucose monitoring during pregnancy Moderate
rs116745876 C allele is associated with elevated fasting glucose during pregnancy (gestational weeks 14-16), suggesting increased gestational hyperglycemia risk.
Discuss glucose screening protocol with provider during pregnancy planning and pregnancy