rs11674248 - UBXN2A
Magnitude 2.2 · 1 study on file
Reported associations
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Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population - Unknown journal (n.d.) · Unknown authors · PubMed 23251661
ABSTRACT: Genetic variants responsible for susceptibility to obesity and its comorbidities among Hispanic children have not been identified. The VIVA LA FAMILIA Study was designed to genetically map childhood obesity and associated biological processes in the Hispanic population. A genome-wide association study (GWAS) entailed genotyping 1.1 million single nucleotide polymorphisms (SNPs) using the Illumina Infinium technology in 815 children. Measured genotype analysis was performed between genetic markers and obesity-related traits i.e., anthropometry, body composition, growth, metabolites, hormones, inflammation, diet, energy expenditure, substrate utilization and physical activity. Identified genome-wide significant loci: 1) corroborated genes implicated in other studies (MTNR1B, ZNF259
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Weight management through diet and exercise Moderate
SNP is associated with increased obesity risk; lifestyle factors significantly modulate weight outcomes.
Discuss weight management strategies with healthcare provider.
Screening
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Body mass index and waist circumference Moderate
SNP is significantly associated with obesity-related traits; carriers have increased genetic predisposition.