Expressive

rs11673316 - Metazoa_SRP - CREB3L3

Magnitude 2.2 · 1 study on file

Reported associations

  • Pleiotropic genetic architecture and novel loci for C-reactive protein levels - Unknown journal (n.d.) · Unknown authors · PubMed 36376304

    ABSTRACT: C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • lipid panel including LDL cholesterol Moderate

    rs11673316 T allele associates with elevated LDL levels in large GWAS; periodic measurement confirms individual risk status

    lipid panel every 1-2 years or per doctor guidance

Diet

  • reduce saturated fat and increase dietary fiber Moderate

    T allele increases LDL levels genetically; reducing saturated fat is evidence-based for LDL management

    saturated fat below 7% of daily calories; increase soluble fiber intake

Discuss with your doctor

  • cardiovascular risk assessment given LDL elevation genetic predisposition Moderate

    Genetic contribution to LDL elevation warrants clinical assessment of overall cardiovascular risk and appropriate preventive strategies

Exercise

  • regular aerobic exercise for cardiovascular health Moderate

    T allele increases LDL levels; regular exercise improves lipid profile and cardiovascular function

    150 minutes moderate aerobic exercise per week, or per doctor guidance