rs11671104 - RAD54L2P1 - LINC01785
Magnitude 2.8 · 1 study on file
Reported associations
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Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer - Unknown journal (n.d.) · Unknown authors · PubMed 24743840
ABSTRACT: Dietary factors, including meat, fruits, vegetables and fiber, are associated with colorectal cancer; however, there is limited information as to whether these dietary factors interact with genetic variants to modify risk of colorectal cancer. We tested interactions between these dietary factors and approximately 2.7 million genetic variants for colorectal cancer risk among 9,287 cases and 9,117 controls from ten studies. We used logistic regression to investigate multiplicative gene-diet interactions, as well as our recently developed Cocktail method that involves a screening step based on marginal associations and gene-diet correlations and a testing step for multiplicative interactions, while correcting for multiple testing using weighted hypothesis testing. Per quartile incre
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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dietary fiber from whole grains and vegetables Moderate
Higher fiber intake is protective against colorectal cancer; this SNP shows diet-dependent colorectal cancer association
Increase daily intake to 25-30g from whole grains, legumes, fruits, and vegetables
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excessive red and processed meat Moderate
High red and processed meat intake increases colorectal cancer risk; this SNP shows diet-mediated colorectal cancer association
Limit red meat to less than 2 servings weekly; minimize processed meat consumption
Screening
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colorectal cancer risk assessment and screening Moderate
This SNP is associated with increased colorectal cancer risk; early screening discussion is indicated
Discuss with physician about risk level and appropriate screening timing/frequency