rs11670704 - PDE4A
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis - Unknown journal (n.d.) · Unknown authors · PubMed 39885523
ABSTRACT: Background Psoriasis is a common chronic, recurrent, immune-mediated disease involved in the skin or joints or both. However, deeper insight into the genetic susceptibility of psoriasis is still unclear. Methods Here we performed the largest multi-ancestry meta-analysis of genome-wide association study including 28,869 psoriasis cases and 443,950 healthy controls. Results We identified 74 genome-wide significant loci for psoriasis. Of 74 loci, 32 were novel psoriasis risk loci. Across 74 loci, 801 likely causal genes are indicated and 164 causal genes are prioritized. SNP-based heritability analyses demonstrated that common variants explain 15% of genetic risk for psoriasis. Gene-set analyses and the genetic correlation revealed that psoriasis-related genes have the positive corr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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psoriasis genetic risk and early detection Moderate
PDE4A rs11670704 T allele associated with elevated psoriasis risk in large GWAS study
discuss genetic risk and preventive strategies with dermatologist
Screening
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psoriasis skin monitoring Moderate
PDE4A rs11670704 T allele associated with elevated psoriasis risk in large GWAS study
monthly self-examination for skin plaques or annual dermatology evaluation