rs11665213 - MIR4527HG

Magnitude 4.5 · 1 study on file

Reported associations

• Longitudinal analysis to better characterize Asthma-COPD overlap syndrome: Findings from an adult asthma cohort in Korea (COREA). - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020) · Park SY, Jung H, Kim JH, Seo B, Kwon OY, Choi S, Oh B, Kwon HS, Cho YS, Moon HB, Won S, Park T, Kim TB · PubMed 30657218

  Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS), which has received much attention, has not been unanimously defined. In this study, we tried to demonstrate that longitudinally defined ACOS is more useful in the real world than blending patients with asthma and COPD. The study patients had undergone two consecutive pulmonary function tests measured at least 3 months apart (n = 1889). We selected the patients who had positive bronchodilator response or methacholine provocation tests (n = 959). Next, we defined ACOS as a patient with a persistent airflow obstruction [forced expiratory volume in 1 second (FEV1)/forced vital capacity <0.7] that was identified twice consecutively by an interval of at least 3 months (n = 228). The proportions of patients who

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