rs116606947 - C2
Magnitude 2.2 · 1 study on file
Reported associations
-
Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis - Unknown journal (n.d.) · Unknown authors · PubMed 39885523
ABSTRACT: Background Psoriasis is a common chronic, recurrent, immune-mediated disease involved in the skin or joints or both. However, deeper insight into the genetic susceptibility of psoriasis is still unclear. Methods Here we performed the largest multi-ancestry meta-analysis of genome-wide association study including 28,869 psoriasis cases and 443,950 healthy controls. Results We identified 74 genome-wide significant loci for psoriasis. Of 74 loci, 32 were novel psoriasis risk loci. Across 74 loci, 801 likely causal genes are indicated and 164 causal genes are prioritized. SNP-based heritability analyses demonstrated that common variants explain 15% of genetic risk for psoriasis. Gene-set analyses and the genetic correlation revealed that psoriasis-related genes have the positive corr
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
genetic psoriasis risk and prevention strategies Moderate
identified genetic risk variant warrants discussion of personalized prevention, symptom recognition, and management approaches
schedule consultation with healthcare provider to discuss genetic risk and prevention options
Lifestyle
-
stress management practice Moderate
psychological stress is a documented psoriasis trigger; genetic risk makes stress mitigation particularly important for disease prevention
establish daily practice such as meditation, yoga, or mindfulness; target 15-30 minutes daily
Screening
-
psoriasis symptom monitoring Moderate
rs116606947-A is associated with elevated psoriasis risk (GWAS p=2e-10); genetic predisposition increases disease probability
review skin monthly for characteristic plaques, scaling, itching; report new symptoms to healthcare provider