rs11660554 - LINC01929 - RNA5SP459

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-Wide Association Study Shows that Executive Functioning Is Influenced by GABAergic Processes and Is a Neurocognitive Genetic Correlate of Psychiatric Disorders - Biological psychiatry (2022) · Hatoum AS, Morrison CL, Mitchell EC, Lam M, Benca-Bachman CE, Reineberg AE, Palmer RHC, Evans LM, Keller MC, Friedman NP · PubMed 36150907

  ABSTRACT: Background: Deficits in executive functions (EFs), cognitive processes that control goal-directed behaviors, are associated with psychopathology and neurological disorders. Little is known about the molecular bases of EF individual differences. Prior candidate gene studies have been underpowered in their search for dopaminergic processes involved in cognitive functioning, and existing EF genome-wide association studies (GWASs) used small sample sizes and/or focused on individual tasks that are imprecise measures of EF. Methods: We conducted a GWAS of a Common EF (cEF) factor score based on multiple tasks in the UK Biobank (N=427,037 European-descent individuals). Results: We found 129 independent genome-wide significant lead variants in 112 distinct loci and that cEF was associat

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