rs116603789 - HLA-F-AS1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections - Unknown journal (n.d.) · Unknown authors · PubMed 28928442
ABSTRACT: Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P < 5 × 10−8) associations in genes with key roles
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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barefoot walking in public moisture areas Moderate
Plantar warts are caused by HPV; this genetic variant increases susceptibility, making transmission avoidance more critical.
Wear shoes or waterproof footwear in pools, locker rooms, communal showers, and public bathing areas.
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foot drying and hygiene Moderate
Plantar warts thrive in moist environments; keeping feet dry reduces HPV colonization and growth opportunity.
Dry feet thoroughly after water exposure; maintain clean, dry feet throughout the day.
Screening
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regular foot inspection for wart development Moderate
Increased genetic susceptibility warrants earlier detection and faster intervention to prevent progression.
Inspect feet weekly for new growths, lesions, or wart-like changes; contact provider if changes appear.