rs116598544 - LINC-ROR - BOD1L2
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans - Unknown journal (n.d.) · Unknown authors · PubMed 35165267
ABSTRACT: Atherosclerosis precedes the onset of clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men; 40 to 60 years) resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci for mean-max cIMT, SIRPA (p = 4.7E-08), and FBXL17 (p = 2.5E-08), were identified. Sex-stratified analysis revealed associations with one male-specific locus, SNX29 (p = 6.3E-09), and two female-specific loci, LARP6 (p = 2.4E-09) and PROK1 (p = 1.0E-08). We replicate previous cIMT associations with different lead S
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Carotid intima-media thickness ultrasound screening Moderate
Genetic variant associated with increased carotid intima-media thickness, an independent marker of subclinical atherosclerosis and cardiovascular risk.
Baseline carotid ultrasound at age 40-50 or earlier with cardiovascular risk factors; repeat as clinically indicated