rs116571378 - ARHGAP25

Magnitude 2.0 · 1 study on file

Reported associations

• Identification of novel genes influencing eosinophil-specific protein levels in asthma families. - The Journal of allergy and clinical immunology (2022) · Vernet R, Matran R, Zerimech F, Madore AM, Lavoie ME, Gagnon PA, Mohamdi H, Margaritte-Jeannin P, Siroux V, Dizier MH, Demenais F, Laprise C, Nadif R, Bouzigon E · PubMed 35671886

  Eosinophils play a key role in the asthma allergic response by releasing cytotoxic molecules such as eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN) that generate epithelium damages. We sought to identify genetic variants influencing ECP and EDN levels in asthma-ascertained families. We performed univariate and bivariate genome-wide association analyses of ECP and EDN levels in 1018 subjects from the EGEA study with follow-up in 153 subjects from the Saguenay-Lac-Saint-Jean study and combined the results of these 2 studies through meta-analysis. We then conducted Bayesian statistical fine mapping together with quantitative trait locus and functional annotation analyses to identify the most likely functional genetic variants and candidate genes. We identified 5 gen

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