Expressive

rs11656775 - RAI1

Magnitude 2.2 · 2 studies on file

Reported associations

  • An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans - Unknown journal (n.d.) · Unknown authors · PubMed 28566273

    ABSTRACT: To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association signals were followed up in additional data sets (of 14,545 or 7,397 T2D case and 38,994 or 71,604 control subjects). We identified 13 novel T2D-associated loci (P < 5 × 10−8), including variants near the GLP2R, GIP, and HLA-DQA1 genes. Our analysis brought the total number of independent T2D associations to 128 distinct signals at 113 loci. Despite substantially increased sample size and more complete coverage of low-frequency variation, all novel associations w

  • Multi-trait GWAS for diverse ancestries: mapping the knowledge gap - Unknown journal (n.d.) · Unknown authors · PubMed 38627641

    ABSTRACT: Background Approximately 95% of samples analyzed in univariate genome-wide association studies (GWAS) are of European ancestry. This bias toward European ancestry populations in association screening also exists for other analyses and methods that are often developed and tested on European ancestry only. However, existing data in non-European populations, which are often of modest sample size, could benefit from innovative approaches as recently illustrated in the context of polygenic risk scores. Methods Here, we extend and assess the potential limitations and gains of our multi-trait GWAS pipeline, JASS (Joint Analysis of Summary Statistics), for the analysis of non-European ancestries. To this end, we conducted the joint GWAS of 19 hematological traits and glycemic traits acro

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Fasting glucose and HbA1c Moderate

    Variant associated with changes in glycemic traits in large population studies

    Monitor fasting glucose and HbA1c every 6 to 12 months

Screening

  • Enhanced diabetes screening Moderate

    Genetic variant associated with increased type 2 diabetes risk (OR 1.05 per risk allele)

    Discuss screening strategy with doctor, including baseline fasting glucose and HbA1c testing