rs11656155 - LINC02073 - CA10
Magnitude 2.2 · 1 study on file
Reported associations
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Pathway analysis of a genome-wide gene by air pollution interaction study in asthmatic children - Unknown journal (n.d.) · Unknown authors · PubMed 31028280
ABSTRACT: Objectives: We aimed to investigate the role of genetics in the respiratory response of asthmatic children to air pollution, with a genome-wide level analysis of gene by nitrogen dioxide (NO2) and carbon monoxide (CO) interaction on lung function and to identify biological pathways involved. Methods: We used a two-step method for fast linear mixed model computations for genome-wide association studies, exploring whether variants modify the longitudinal relationship between 4-month average pollution and post-bronchodilator FEV1 in 522 Caucasian and 88 African-American asthmatic children. Top hits were confirmed with classic linear mixed-effect models. We used the improved gene-set enrichment analysis for GWAS (i-GSEA4GWAS) to identify plausible pathways. Results: Two SNPs near the
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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High NO2 air pollution exposure Moderate
T allele at rs11656155 modifies lung function susceptibility to NO2 in asthma
Monitor local NO2 air quality; limit outdoor activity on high pollution days
Screening
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Annual lung function testing if asthma Moderate
T allele carriers show altered FEV1 response to NO2 pollution
Spirometry annually; discuss with doctor regarding baseline and trend monitoring