rs11655964 - CASC17

Magnitude 2.2 · 1 study on file

Reported associations

• Effect of genetic variants in UBE2O and TPK1 on facial morphology of Koreans - Unknown journal (n.d.) · Unknown authors · PubMed 37415797

  ABSTRACT: Abstract Human face is a highly heritable and complex trait. Many genome-wide analyses have identified genetic variants influencing facial morphology. Genome-wide association studies (GWASs) investigating facial morphologies of different populations provide a comprehensive insight into the genetic basis of the human face. Here, we report a GWAS of normal facial variation in Koreans using an array optimized for the Korean population (KoreanChip). We found that novel genetic variants encompassing four loci reached the genome-wide significance threshold. They include LOC107984547, UBE2O, TPK1, and LINC01148 loci associated with facial angle, brow ridge protrusion, nasal height, and eyelid curvature. Our results also validated previously published genetic loci, including FAT4, SOX9,

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