rs116555978 - IGBP1P3 - RPL30P4
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas - Unknown journal (n.d.) · Unknown authors · PubMed 38714721
ABSTRACT: Adverse pregnancy outcomes (APOs) affect a large proportion of pregnancies and represent an important cause of morbidity and mortality worldwide. Yet the pathophysiology of APOs is poorly understood, limiting our ability to prevent and treat these conditions. To search for genetic markers of maternal risk for four APOs, we performed multi-ancestry genome-wide association studies (GWAS) for pregnancy loss, gestational length, gestational diabetes, and preeclampsia. We clustered participants by their genetic ancestry and focused our analyses on three sub-cohorts with the largest sample sizes: European, African, and Admixed American. Association tests were carried out separately for each sub-cohort and then meta-analyzed together. Two novel loci were significantly associated with an
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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preeclampsia risk assessment before pregnancy Moderate
This variant shows 2.4-fold association with preeclampsia in first pregnancies based on large population study
Discuss with OB-GYN when planning pregnancy or at first prenatal visit
Screening
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blood pressure screening during pregnancy Moderate
Early detection of elevated blood pressure is critical for preeclampsia management in high-risk individuals
Regular monitoring at each prenatal visit starting early in pregnancy