rs11653989 - MGAT5B - Metazoa_SRP

Magnitude 4.5 · 1 study on file

Reported associations

• A Meta-Analysis of Genome-Wide Association Studies of the Electrocardiographic Early Repolarization Pattern - Unknown journal (n.d.) · Unknown authors · PubMed 22683750

  ABSTRACT: Background The early repolarization pattern (ERP) is common and associated with risk of sudden cardiac death. ERP is heritable and mutations have been described in syndromatic cases. Objective To conduct a meta-analysis of genome-wide association studies (GWAS) to identify common genetic variants influencing ERP. Methods We ascertained ERP based on electrocardiograms in three large community-based cohorts from Europe and the US: the Framingham Heart Study, the Health 2000 Study, and the KORA F4 Study. We analyzed GWAS in participants with and without ERP by logistic regression assuming an additive genetic model and meta-analyzed individual cohort results. We then sought to strengthen support for findings that reached p≤1×10−5 in independent individuals by direct genotyping o

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