rs11652874 - ASIC2

Magnitude 2.2 · 1 study on file

Reported associations

• The Novel ASIC2 Locus is Associated with Severe Gingival Inflammation - Unknown journal (n.d.) · Unknown authors · PubMed 28459102

  ABSTRACT: An increasing body of evidence suggests a significant genetic regulation of inflammatory response mechanisms; however, little is known regarding the genetic determinants of severe gingival inflammation (GI). We conducted a genome-wide association study of severe GI among 4077 European American adults, participants in the Dental Atherosclerosis Risk In Communities cohort. The severe GI trait was defined dichotomously using the 90th percentile of gingival index ≥2 extent score. Genotyping was performed with the Affymetrix 6.0 array platform and an imputed set of 2.5 million markers, based on HapMap Phase II CEU build 36, was interrogated. Genetic models were based on logistic regression and controlled for ancestry (10 principal components), sex, age, and examination center. One l

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