Expressive

rs1165176 - SLC17A1

Magnitude 2.8 · 1 study on file

Reported associations

  • GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes - Unknown journal (n.d.) · Unknown authors · PubMed 27899376

    ABSTRACT: Objective A genome-wide association study (GWAS) of gout and its subtypes was performed to identify novel gout loci, including those that are subtype-specific. Methods Putative causal association signals from a GWAS of 945 clinically defined gout cases and 1213 controls from Japanese males were replicated with 1396 cases and 1268 controls using a custom chip of 1961 single nucleotide polymorphisms (SNPs). We also first conducted GWASs of gout subtypes. Replication with Caucasian and New Zealand Polynesian samples was done to further validate the loci identified in this study. Results In addition to the five loci we reported previously, further susceptibility loci were identified at a genome-wide significance level (p<5.0×10−8): urate transporter genes (SLC22A12 and SLC17A1) an

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • limiting purine-rich foods Moderate

    Uric acid from dietary purines accumulates in carriers with impaired renal excretion via SLC17A1

    reduce red meat, organ meats, seafood high in purines; emphasize vegetables, dairy, whole grains

Discuss with your doctor

  • genetic gout risk and prevention strategy Moderate

    Strong genetic association (OR=1.42, p=1.47e-9 in Japanese cohort) indicates personalized prevention approach warranted

Screening

  • serum uric acid levels Moderate

    rs1165176 (G allele) impairs SLC17A1-mediated urate excretion, increasing hyperuricemia risk

    measure uric acid baseline, then monitor annually or when symptoms present