Expressive

rs11651681 - SMURF2 - MICOS10P2

Magnitude 4.5 · 1 study on file

Reported associations

  • Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk - Unknown journal (n.d.) · Unknown authors · PubMed 36914875

    ABSTRACT: Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 588,452 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of interve

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Aerobic cardiorespiratory exercise Moderate

    Regular aerobic activity improves respiratory capacity; especially beneficial for those with genetic predisposition to lower lung function.

    150 minutes moderate-intensity aerobic exercise per week

Lifestyle

  • Air quality and pollution exposure Moderate

    Air pollutants are inflammatory and damage respiratory epithelium; effects are more significant in those with genetic predisposition to lower lung function.

    Check air quality index (AQI); limit outdoor activity on high pollution days

  • Cigarette smoking Moderate

    Smoking further reduces lung function; individuals with genetic predisposition to lower FEV1/FVC face compounded respiratory risk.

Screening

  • Baseline pulmonary function testing Moderate

    Genetic variant associated with reduced lung function (FEV1/FVC ratio); baseline spirometry establishes individual respiratory capacity.

    Spirometry by age 30-35, repeat every 3-5 years if normal