rs116515271 - LINC01781 - MTND2P30
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic modifiers of asthma response to air pollution in children: An African ancestry GWAS and PM polygenic risk score study. - Environmental research (2025) · Kelchtermans J, March ME, Mentch F, Qu H, Liu Y, Nguyen K, Hakonarson H · PubMed 39725137
Ambient air pollution (AAP) is linked to asthma outcomes, but predicting individual risk remains challenging. Understanding genetic contributors to AAP sensitivity may help overcome this gap. To determine if single nucleotide polymorphisms (SNPs) are associated with AAP sensitivity in children with asthma. We complete a GWAS in pediatric patients with asthma frequently exposed to AAP, comparing patients with exacerbations following spikes in AAP to patients without this temporal association and calculate a polygenic risk score (PRS) for PM . This PRS was validated using internal data and data from the All of Us cohort. We included 6023 patients in the GWAS, restricted to the African ancestry cohort due to the association between AAP exposure and race. Three loci reached genome-wide signifi
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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personalized asthma management for ozone sensitivity Moderate
Genetic predisposition to ozone-induced exacerbations may warrant tailored preventive or treatment approaches
Discuss ozone sensitivity with physician; consider preventive medications for high-pollution days
Lifestyle
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outdoor exertion during high ozone days Moderate
Carriers show significantly increased asthma exacerbation risk when exposed to elevated ambient ozone
Check daily AQI; limit strenuous outdoor activity when ozone exceeds 100 ppb 8-hour average
Screening
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asthma symptoms and lung function Moderate
SNP is associated with increased risk of ozone-triggered asthma exacerbations in air pollution-exposed children
Annual spirometry if asthma present; track symptoms during high-ozone days