rs11651078 - CCDC144NL-AS1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide gene-bisphenol A, F and triclosan interaction analyses on urinary oxidative stress markers. - The Science of the total environment (2021) · Zhong R, He H, Jin M, Lu Z, Deng Y, Liu C, Shen N, Li J, Wang H, Ying P, Li B, Zeng Q, Lu Q, Cheng L, Zhu Y, Miao X, Tian J · PubMed 34619205

  Bisphenols and triclosan (TCS) are common endocrine disrupters (EDCs) that may induce oxidative stress. However, there is limited information as to whether these EDCs interact with genetic variants to modify the levels of oxidative stress on a genome-wide scale. We first performed a genome-wide scan among a Chinese population and also measured three urinary EDCs, including bisphenol A (BPA), bisphenol F (BPF) and TCS, and three urinary oxidative stress markers [4-hydroxy-2-nonenal-mercapturic acid (HNE-MA), 8-iso-prostaglandin-F (8-isoPGF ) and 8-hydroxy-deoxyguanosine (8-OHdG)]. Subsequently, we examined interactions between three urinary EDCs and nearly 4.6 million genetic variants for three urinary oxidative stress markers by the general linear model. Urinary BPA, BPF and TCS were posit

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