Expressive

rs11650511 - CRK

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome‐Wide Assessment of Shared Genetic Architecture Between Rheumatoid Arthritis and Cardiovascular Diseases - Unknown journal (n.d.) · Unknown authors · PubMed 37947095

    ABSTRACT: Background Patients with rheumatoid arthritis (RA) have a 2‐ to 10‐fold increased risk of cardiovascular disease (CVD), but the biological mechanisms and existence of causality underlying such associations remain to be investigated. We aimed to investigate the genetic associations and underlying mechanisms between RA and CVD by leveraging large‐scale genomic data and genetic cross‐trait analytic approaches. Methods and Results Within UK Biobank data, we examined the genetic correlation, shared genetics, and potential causality between RA (Ncases=6754, Ncontrols=452 384) and cardiovascular diseases (CVD, Ncases=44 238, Ncontrols=414 900) using linkage disequilibrium score regression, cross‐trait meta‐analysis, and Mendelian randomization. We observed significant

  • Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits - Unknown journal (n.d.) · Unknown authors · PubMed 39537608

    ABSTRACT: Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of PLEC in the heart left ventricle, and rs7529220, which colocalised with Alzheimer's disease, atrial fibrillation and expression of C1Q family genes. Single-cell RNA-sequencing data, co-expression network and protein-protein interaction analyses provided evidence for different mechanisms of PLEC, which is upregulated in left ventricular endothelium and cardiomyocyte

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • high sodium intake Moderate

    Sodium restriction is a primary intervention for hypertension; this variant's association with elevated blood pressure suggests increased benefit.

    Maintain intake below 2300 mg/day, ideally below 1500 mg/day

Discuss with your doctor

  • blood pressure management and medication strategies Moderate

    This variant predisposes to hypertension; early discussion with provider about prevention and management options is advisable.

Exercise

  • regular aerobic exercise Moderate

    Aerobic exercise reduces blood pressure; individuals with this genetic predisposition may benefit from consistent cardiovascular activity.

    150 minutes/week moderate-intensity aerobic activity

Lifestyle

  • weight management if overweight Moderate

    Excess body weight increases blood pressure; this variant's effect may be compounded by overweight status.

    Achieve BMI 18.5-24.9 kg/m2 if currently overweight

Screening

  • systolic blood pressure monitoring Moderate

    This variant is strongly associated with elevated systolic blood pressure (p<1e-12) and hypertension; regular monitoring enables early detection.

    Annual screening, or more frequent if baseline is elevated