rs11650066 - ASIC2

Magnitude 2.0 · 1 study on file

Reported associations

• A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. - Nature genetics (2011) · Unknown authors · PubMed 21378988

  Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)¹^-7, a modest number considering the apparent heritability of CAD^8. All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with ∼575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 × 10^-8 in the combined discovery and replication analy

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