rs11647428 - PKD1L2

Magnitude 2.0 · 1 study on file

Reported associations

• Assessing the causal association of glycine with risk of cardio-metabolic diseases - Unknown journal (n.d.) · Unknown authors · PubMed 30837465

  ABSTRACT: Circulating levels of glycine have previously been associated with lower incidence of coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains uncertain if glycine plays an aetiological role. We present a meta-analysis of genome-wide association studies for glycine in 80,003 participants and investigate the causality and potential mechanisms of the association between glycine and cardio-metabolic diseases using genetic approaches. We identify 27 genetic loci, of which 22 have not previously been reported for glycine. We show that glycine is genetically associated with lower CHD risk and find that this may be partly driven by blood pressure. Evidence for a genetic association of glycine with T2D is weaker, but we find a strong inverse genetic effect of hyperinsulinaem

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