Expressive

rs1164660 - FOLH1 - NOX4P1

Magnitude 2.2 · 1 study on file

Reported associations

  • The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study - Unknown journal (n.d.) · Unknown authors · PubMed 33097823

    ABSTRACT: Appendicular lean mass (ALM) is a heritable trait associated with loss of lean muscle mass and strength, or sarcopenia, but its genetic determinants are largely unknown. Here we conducted a genome-wide association study (GWAS) with 450,243 UK Biobank participants to uncover its genetic architecture. A total of 1059 conditionally independent variants from 799 loci were identified at the genome-wide significance level (p < 5 × 10−9), all of which were also significant at p < 5 × 10-5 in both sexes. These variants explained ~15.5% of the phenotypic variance, accounting for more than one quarter of the total ~50% GWAS-attributable heritability. There was no difference in genetic effect between sexes or among different age strata. Heritability was enriched in cer

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • adequate protein intake Moderate

    Muscle protein synthesis requires sufficient dietary amino acids; lean mass maintenance depends on protein availability

    1.6-2.2 g per kg body weight daily

Exercise

  • resistance training for lean mass Moderate

    FOLH1 variants affect appendicular lean mass; resistance training optimizes muscle maintenance and functional capacity

    3+ sessions weekly targeting major muscle groups

Screening

  • lean mass assessment via dual-energy X-ray absorptiometry Moderate

    FOLH1 variants affect appendicular lean mass; periodic measurement enables early detection of decline

    Baseline assessment, then every 2-3 years