rs11643561 - ANKRD11
Magnitude 2.2 · 1 study on file
Reported associations
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Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome - Unknown journal (n.d.) · Unknown authors · PubMed 39349817
ABSTRACT: Metabolic syndrome (MetS) is a complex hereditary condition comprising various metabolic traits as risk factors. Although the genetics of individual MetS components have been investigated actively through large-scale genome-wide association studies, the conjoint genetic architecture has not been fully elucidated. Here, we performed the largest multivariate genome-wide association study of MetS in Europe (nobserved = 4,947,860) by leveraging genetic correlation between MetS components. We identified 1,307 genetic loci associated with MetS that were enriched primarily in brain tissues. Using transcriptomic data, we identified 11 genes associated strongly with MetS. Our phenome-wide association and Mendelian randomization analyses highlighted associations of MetS with diverse di
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Annual fasting lipid panel and glucose Moderate
Baseline and periodic assessment of these key markers detects early metabolic dysfunction in carriers of metabolic syndrome risk alleles.
Fasting lipid panel and glucose annually, more often if abnormal
Exercise
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Regular aerobic exercise Moderate
Metabolic syndrome risk associated with this variant responds to aerobic exercise as a primary preventive intervention.
150 minutes of moderate-intensity aerobic activity weekly
Screening
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Metabolic syndrome screening Moderate
rs11643561 shows significant association with metabolic syndrome (p=6e-10, n=1.3M); systematic screening enables early detection of dysmetabolic traits.
Screen at baseline and every 1-2 years