Expressive

rs116434579 - TRIB2 - LINC00276

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors. - American journal of human genetics (2017) · Ahola-Olli AV, Würtz P, Havulinna AS, Aalto K, Pitkänen N, Lehtimäki T, Kähönen M, Lyytikäinen LP, Raitoharju E, Seppälä I, Sarin AP, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salomaa V, Salmi M, Kettunen J, Raitakari OT · PubMed 27989323

    Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide association study (GWAS) of up to 8,293 Finns we identified 27 genome-widely significant loci (p < 1.2 × 10 ) for one or more cytokines. Fifteen of the associated variants had expression quantitative trait loci in whole blood. We provide genetic instruments to clarify the causal roles of cytokine signaling and upstream inflammation in immune-related and other chronic diseases. We further link inflammatory markers with variants previously associated with autoimmune diseases such as Crohn disease, multiple sclerosis, and ulcerative colitis and hereby elucidate the molecular mechanisms underpinning these diseases and suggest potential dru

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • anti-inflammatory dietary patterns Moderate

    Elevated TNF-alpha is pro-inflammatory; Mediterranean and DASH diets reduce TNF-alpha and cardiovascular risk.

    Mediterranean-style eating: emphasize olive oil, fish, whole grains, nuts, vegetables

Exercise

  • aerobic exercise Moderate

    Regular aerobic activity reduces TNF-alpha levels and systemic inflammation.

    150 minutes moderate-intensity aerobic activity weekly, or 75 minutes vigorous-intensity

Lifestyle

  • body weight Moderate

    Obesity increases TNF-alpha secretion from adipose tissue; weight reduction lowers TNF-alpha.

    Maintain BMI <25; if overweight, aim for 5-10 percent weight loss

  • stress management practice Moderate

    Chronic stress and elevated cortisol increase TNF-alpha; stress reduction techniques lower TNF-alpha.

    Daily mindfulness or meditation, 10-20 minutes; or regular yoga or tai chi practice

Screening

  • cardiovascular risk screening Moderate

    Elevated TNF-alpha is an independent cardiovascular risk factor; early screening and risk reduction are recommended.

    Discuss baseline lipid panel, blood pressure, glucose, and CVD risk score with physician