rs11643425 - XYLT1

Magnitude 4.5 · 1 study on file

Reported associations

• Multiomics analyses prioritize disease genes and pathways in hidradenitis suppurativa. - The Journal of investigative dermatology (2026) · Peacker BL, Ly L, Hwang JC, Gravel-Pucillo K, Zheng C, Wheless LE, Ferolito BR, Cho K, Gaziano JM, Pereira AC, Hartman RI · PubMed 41548865

  Hidradenitis suppurativa is a chronic inflammatory skin condition associated with an increased risk of all-cause mortality. Although it is known to be influenced by genetic and environmental factors, the genetic contributors remain poorly characterized. We performed a large-scale meta-analysis involving patients from the Million Veteran Program, UK Biobank, and FinnGen, including a total of 3941 cases and 1,435,603 controls. We identified 9 genome-wide significant loci, 5 of which have not been previously reported. Using a variant-to-gene analysis pipeline, we mapped these variants to 11 lead genes, supporting prior candidates while revealing previously unreported ones, to our knowledge, including SMPD4 and PSMA4, which we demonstrate are differentially expressed in hidradenitis suppurativ

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